Job Description

Application Window Open date: January 10, 2025 Most recent review date: Wednesday, Apr 30, 2025 at 11:59pm (Pacific Time) Applications received after this date will be reviewed by the search committee if the position has not yet been filled. Final date: Friday, Jul 10, 2026 at 11:59pm (Pacific Time) Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled. Position description The UCSF Division of Cardiology/Cardiovascular Research Institute (CVRI) is seeking a highly motivated and skilled full-time Histology Technician to support cutting-edge research on cardiovascular biology using primarily mouse models (embryonic and adult). The successful candidate will play a critical role in the preparation, analysis, and imaging of tissue samples, contributing to groundbreaking discoveries in the field. Key Responsibilities: * Tissue Preparation and Sectioning: o Perform fixation, processing, and embedding of mouse tissues (both embryonic and adult) for histological analysis. o Section tissues using microtomy (paraffin) and cryotomy (frozen) techniques with high precision. * Histological and Molecular Staining: o Execute standard histological stains (e.g., H&E, Masson's trichrome). o Conduct specialized staining protocols, including immunohistochemistry (IHC), immunofluorescence (IF), and advanced RNA in situ hybridization techniques such as RNAscope. o Optimize and troubleshoot staining protocols as required. * Microscopy and Structural Identification: o Utilize light, fluorescent, and confocal microscopy to analyze stained tissue samples. o Identify and document key structures of interest, ensuring accuracy and relevance to specific research objectives. o Collaborate with researchers to confirm findings and provide interpretative input when necessary. * Spatial Transcriptomics: o Gain and apply expertise in spatial transcriptomic technologies to map gene expression within tissue samples. o Prepare and process tissue for spatial transcriptomic experiments, adhering to rigorous quality control standards. o Collaborate with bioinformatics teams to integrate spatial data into broader research contexts. * Data Documentation and Quality Control: o Maintain accurate and detailed records of all sample preparation, staining protocols, and analytical results. o Ensure consistency and reproducibility of histological processes by adhering to established standard operating procedures (SOPs). o Participate in the evaluation and implementation of new technologies and methods to enhance histological capabilities. * Lab Collaboration and Communication: o Work closely with a multidisciplinary team of researchers, including molecular biologists, physiologists, and bioinformaticians. o Provide technical support and training to team members as needed. o Attend and contribute to lab meetings, presenting data and updates on histological findings. Required qualifications:

• Bachelor's degree in biology, biochemistry, molecular biology, or a related science field OR at least four years of research experience.
• Hands-on experience in tissue preparation, sectioning, and a variety of staining techniques (e.g., RNAscope, IHC, IF).
• Proficiency with microscopy (light, fluorescence, confocal) and identifying tissue structures.
• Familiarity with or willingness to learn spatial transcriptomic techniques.
• Strong attention to detail and excellent organizational skills.
• Ability to work both independently and collaboratively in a dynamic research environment.

Preferred qualifications:

• Experience with mouse models and tissue handling.
• Knowledge of cardiovascular biology or related research fields.
• Competence in troubleshooting and optimizing histological protocols.

Please apply online at Applicants' materials must list current and/or pending qualifications upon submission. See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100-$56,600. Application Requirements Document requirements Curriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.). Cover Letter (Optional) Statement of Research Statement of Teaching (Optional) Statement of Contributions to Diversity - Please see the following page for more details: Contributions to Diversity Statement (Optional) Misc / Additional (Optional) Reference requirements 3-5 required (contact information only) About UC San Francisco As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements. The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law. As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct. * "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, discrimination, dishonesty, or unethical conduct, as defined by the employer. * UC Sexual Violence and Sexual Harassment Policy: * UC Anti-Discrimination Policy: * APM - 035: Affirmative Action and Nondiscrimination in Employment: Job location San Francisco, CA #J-18808-Ljbffr University of California - San Francisco

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Full time, Local area,

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